Gilbert Di Paolo Selected Research

Progranulins

1/2023	Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia.
1/2022	Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
1/2021	Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.

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Gilbert Di Paolo Research Topics

Disease

18	Alzheimer Disease (Alzheimer's Disease) 11/2023 - 12/2006
7	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2023 - 05/2011
3	Frontotemporal Dementia (Semantic Dementia) 02/2024 - 01/2021
3	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2023 - 12/2012
3	Down Syndrome (Down's Syndrome) 01/2018 - 07/2008
3	Neoplasms (Cancer) 10/2017 - 11/2012
2	Tauopathies 11/2023 - 12/2012
2	Parkinson Disease (Parkinson's Disease) 10/2023 - 01/2017
2	Neointima 01/2022 - 01/2019
2	Atherosclerosis 01/2018 - 01/2016
2	Amyloid Plaque 12/2017 - 11/2017
2	Neoplasm Metastasis (Metastasis) 10/2017 - 11/2012
2	Parkinsonian Disorders (Parkinsonism) 04/2015 - 09/2013
1	Disease Progression 02/2024
1	Crohn Disease (Crohn's Disease) 10/2023
1	Virus Diseases (Viral Diseases) 01/2023
1	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2023
1	Vascular Diseases (Vascular Disease) 01/2022
1	Multiple Sclerosis 01/2021
1	Sepsis (Septicemia) 01/2021
1	Neuroinflammatory Diseases 01/2020
1	Demyelinating Diseases (Demyelinating Disease) 01/2020
1	Mucopolysaccharidosis II (Hunter Syndrome) 01/2020
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2020
1	Central Nervous System Diseases (CNS Diseases) 01/2020
1	Osteosarcoma (Osteogenic Sarcoma) 01/2020
1	Hyperplasia 01/2019
1	Fibrosis (Cirrhosis) 01/2019
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Pathologic Processes 01/2019
1	Vascular System Injuries 01/2019
1	Pneumonia (Pneumonitis) 01/2019
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2019
1	Hypertrophy 05/2018
1	Infarction (Infarctions) 05/2018
1	Atherosclerotic Plaque (Atheroma) 01/2018
1	Memory Disorders (Memory Loss) 01/2018
1	Breast Neoplasms (Breast Cancer) 10/2017
1	Body Weight (Weight, Body) 01/2017
1	Insulin Resistance 01/2017
1	Obesity 01/2017
1	Weight Gain 01/2017
1	Non-alcoholic Fatty Liver Disease 12/2016
1	Dyslipidemias (Dyslipidemia) 10/2016
1	Fatty Liver 01/2016
1	Congenital Structural Myopathies (Centronuclear Myopathy) 01/2016

Drug/Important Bio-Agent (IBA)

14	LipidsIBA 01/2023 - 08/2010
7	Proteins (Proteins, Gene)FDA Link 11/2023 - 04/2015
6	Amyloid (Amyloid Fibrils)IBA 12/2017 - 10/2012
6	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2016 - 07/2003
5	1-dodecylpyridoxal (PLD)IBA 01/2022 - 01/2010
4	CholesterolIBA 11/2023 - 05/2011
4	EnzymesIBA 01/2020 - 08/2010
4	Phosphatidic Acids (Phosphatidic Acid)IBA 01/2019 - 08/2010
4	synaptojaninIBA 01/2018 - 07/2008
4	Peptides (Polypeptides)IBA 12/2017 - 10/2012
4	phospholipase D1IBA 12/2016 - 01/2010
3	ProgranulinsIBA 01/2023 - 01/2021
3	Phospholipase DIBA 01/2019 - 08/2010
2	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2018
2	ApolipoproteinsIBA 11/2023 - 01/2022
2	Apolipoprotein E4IBA 11/2023 - 01/2022
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2019
2	Flavin-Adenine Dinucleotide (FAD)IBA 01/2018 - 12/2006
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2017 - 11/2017
2	phospholipase D2IBA 10/2017 - 12/2010
2	SynucleinsIBA 01/2017 - 04/2015
2	Triglycerides (Triacylglycerol)IBA 12/2016 - 10/2016
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 12/2012
1	Apolipoprotein E3IBA 11/2023
1	Apolipoproteins E (ApoE)IBA 11/2023
1	Phosphotransferases (Kinase)IBA 10/2023
1	Leucine (L-Leucine)FDA Link 10/2023
1	bis(monoacylglyceryl)phosphateIBA 01/2023
1	AntibodiesIBA 01/2022
1	CardiotoxinsIBA 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2020
1	Phospholipases (Phospholipase)IBA 01/2020
1	Iduronic Acid (Iduronate)IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	indium-bleomycinIBA 01/2019
1	GlucocorticoidsIBA 01/2019
1	Mitochondrial DNA (mtDNA)IBA 01/2019
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2019
1	HydrogelsIBA 05/2018
1	SynaptophysinIBA 01/2018
1	oxidized low density lipoproteinIBA 01/2018
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 10/2017
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Steroid 12-alpha-Hydroxylase (CYP8B1)IBA 01/2017
1	Apolipoproteins B (ApoB)IBA 10/2016
1	LDL Receptors (LDL Receptor)IBA 01/2016
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2016
1	Bile Acids and Salts (Bile Acids)IBA 01/2016
1	HDL LipoproteinsIBA 01/2016
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2016

Therapy/Procedure

5	Therapeutics 11/2022 - 11/2012
1	Ligation 01/2022
1	Enzyme Therapy 01/2020
1	Fat-Restricted Diet (Diet, Fat Restricted) 01/2017